Maaka Karin comes from a family of vampires living in Japan, but she is not a normal vampire. Vampires are normally supposed to drink the blood of their victims... but Karin suffers from a condition that causes her body to produce excessive amounts of blood. About once a month, she has to get rid of the excess blood by giving it to her "victims". But she somehow manages... and goes to school like everyone else her age.Well, things are about to get more complicated: When a new student, Usui Kenta transfers into Karin's class, she starts producing unusually huge amounts of blood, almost as if in reaction to him. Worse, he happens upon Karin's... true nature...

Staz is the vampire boss of a section of the demon world, but he has little interest in human blood. He’s more infatuated with Japanese culture. When he learns that Yanagi Fuyumi, a Japanese teenage girl, accidentally wanders into the demon city, he jumps to the occasion. However, while Staz deals with an intruder on his turf, the oblivious Fuyumi is killed by a monster and becomes a wandering ghost. The disappointed Staz vows to her that he will find a way to bring Fuyumi back to life.

In the distant future...Vampires rule the night, but their numbers are dwindling. With huge bounties on their heads, a class of hunters has emerged, Bounty Hunters. One hunter is unlike all the others. He is a Dunpeal — a half human, half vampire. At war with himself, feared by all, tortured and alone, he is... Vampire Hunter D. — from introD, the infamous dunpeal outcast and renowned vampire hunter has fought for the grudging acceptance among humans through his prowess at hunting the creatures of the night. He is called upon to locate Charlotte Elbourne, the lovely daughter of an affluent family who apparently has been kidnapped by a powerful vampire named Meier Link.Charlotte's father offers a large bounty for her return, be she dead or alive, a task D willingly accepts, even with the notorious Marcus brothers Borgoff, Kyle, Nolt & Grove and their compatriot Leila, seeking the prize as well.As the sun sets, the hunt is on, but as the chase evolves it becomes more and more apparent that some sinister evil lurks in the shadows, secretly plotting and manipulating the hunters' every move. An insidious trap is set, and with the tables turned the hunters become the hunted!

During a fiercely hot summer in Sotoba, a peaceful and quiet village with a population of 1300 people, a series of bizarre deaths begin to occur. At the same time, a strange family moves into a long abandoned mansion in the region. Hospital dean Toshio Ozaki cannot figure out the cause of death in the deceased, initially suspecting an epidemic. As investigations continue between the hospital staff and the residents, it turns out that the village is being attacked by vampires.